Mayor Chokwe Lumumba said this was necessary to "protect our residents" in response to the rise of positive coronavirus cases in the state.
Individuals who don't wear masks could face citations from police officers, while businesses could face stiff penalties, according to Lumumba.
“We could shut you down if you’re not adhering to this,” he said.
While there has not been a statewide order, several cities have mask requirements, including Tupelo, Oxford, and Starkville.